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You may report side effects to FDA at FDA-1088 or at /medwatch. Vision changes such as increased sensitivity to light, blurred vision, or trouble telling blue and green colors apart may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. VIAGRA does not protect against sexually transmitted diseases, including HIV.

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In studies with healthy volunteers of single doses up to 800 mg, adverse reactions were similar to those seen at lower doses but incidence rates and severities were increased. In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for C max and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied.

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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Ophthalmic examination 5 days later showed corrected visual acuities of 20/20 OU and normal color vision in both eyes. Kinetic perimetry revealed an inferior altitudinal visual field depression in the left eye . The right eye had a normal optic nerve with a 0.1 cup-disc ratio.

This type of blindness, which may be permanent, is called non-arteritic anterior ischemic optic neuropathy . Use of sildenafil with epoprostenol may reduce the blood level of sildenafil. The safety and effectiveness of sildenafil in pediatric PAH patients has not been established. But if are dealing with ED, you and your doctor should carefully consider the risk of such problems before you take a PDE5 inhibitor.

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You should make certain that you are not taking these medications before starting sildenafil. Use of sildenafil with medications known as nitrates is CONTRAINDICATED.

  • At one time, medications called nitrates, such as nitroglycerin, were a mainstay of CAD treatment.
  • Confidence intervals (95%) for single samples were calculated for proportions .
  • Vardenafil is more selective than sildenafil and tadalafil to PDE5, which again means a lower dose is needed with potentially less side effects.
  • Sildenafil is available as a generic drug in the United States, labeled for pulmonary arterial hypertension.

In the first years of the Viagra era, research on sildenafil and the heart was devoted to making sure the drug was safe for the circulation. But several studies of patients with congestive heart failure also reported that the medication improves oxygen consumption, pulmonary artery pressure, and exercise capacity in these patients. Another interesting property is sildenafil’s ability to protect the heart from excessive stimulation by adrenaline.